Mini pill pregnancy

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Pregnancy and medicines / Obstetrics and gynecology, reproductive medicine / Articles about health / Articles and encyclopedia / madez.ru

We have been actively planning for a baby for a long time, but we never think about the dangers of drugs during pregnancy!

Gynecologist, gynecologist endocrinologist Popova Natalya Vladimirovna will tell you what medicines can be taken during pregnancy, and which ones are categorically not recommended.

One of the most important periods in a woman's life is the period of bearing a child. And in these few months, the expectant mother must do everything in her power to give birth to a healthy baby. But pregnancy lasts nine calendar months - it is very difficult during this time to never feel any ailments or health problems.

If it is necessary to use any drug during pregnancy, the mother-to-be should remember:

• Any drug during pregnancy (at any stage) can be used only in accordance with the indications and only as prescribed by the attending physician;
• When choosing a medicinal product, preference should be given only to those medicinal products that have proven efficacy;
• Prefer monotherapy, i.e. treatment with only one drug if possible; combined treatment during this period is undesirable;
• Topical treatment is more desirable than systemic (oral, intravenous, intramuscular) administration of the drug.
• A pregnant woman should remember that completely safe and absolutely harmless drugs do not exist.

The most dangerous period for the use of any drugs, both of chemical and natural origin, is considered the first trimester of pregnancy (the first 12 gestational weeks), when all organs and systems are laid in the fetus, which in the future will only develop and form the placenta. It is at this time that the fetus is considered the most vulnerable to any chemical and medicinal substances.

Pronounced mutagenic hazard:

1. in industry - asbestos, acetaldehyde, vinyl chloride, dimethyl sulfate; factors of metallurgical and rubber industries;

Metals: copper, nickel, lead, zinc, cadmium, mercury, chromium, arsenic, styrene, formaldehyde, chloroprene, epichlorohydrin, ethylene oxide.

2. agriculture - a mixture of defoliants, pesticides, insectiosides, repellents, fungicides, pesticides, methylpartion, phthalaphos, chlorophos, gardona, DDT, contan.

If you work in a hazardous industry and come into contact with these chemicals, from early pregnancy, switch to "light work".

Global trends in early pregnancy from the point of view of evidence-based medicine are unambiguous: the need for rational diet therapy , intake of folic acid at least 400 mcg/day and potassium iodide 200 mg/day.

After 12-14 weeks of pregnancy, with an inadequate diet, the use of vitamin preparations during pregnancy and lactation is recommended as a way to improve the health of the mother and fetus . Vitamin complexes intended for other groups of the population (including children) are contraindicated for pregnant women!

Medicines during pregnancy

In existing classifications, it is customary to subdivide drugs during pregnancy into groups - safe, relatively safe, relatively unsafe and dangerous. Moreover, the list of drugs is periodically updated.

1. Category A - safe drugs. Controlled trials have shown no risk to the fetus for the first 12 weeks of pregnancy. Regarding them, there is no evidence of a harmful effect on the fetus in late pregnancy. These are folic acid, levothyroxine sodium, paracetamol, magnesium sulfate.
2. Category B - relatively safe drugs. Experimental studies have generally not shown their teratogenic effects in animals and children whose mothers took such drugs. These are amoxicillin, heparin, insulin, aspirin, metronidazole (except for the first trimester)
3. Category C - relatively unsafe drugs. When testing these drugs on animals, their teratogenic or embryotoxic effects were revealed. Controlled trials have not been conducted or the effect of the drug has not been studied (isoniazid, fluoroquinolones, gentamicin, antidepressants, antiparkinsonian drugs). These drugs should only be used if the potential benefit outweighs the potential risk.
4. Caregory D - dangerous drugs. The use of drugs in this group is associated with a certain risk to the fetus, but despite this, it is possible to use the drug for health reasons (anticonvulsants, doxycycline, kanamycin, diclofenac).
5. Category X - dangerous drugs that are contraindicated for use.
   The teratogenic effect of drugs in this group has been proven, their use is contraindicated during pregnancy, as well as when planning a pregnancy.

Although almost 1000 chemicals are known to be teratogenic in animals, only a few chemicals have been proven to be permanently teratogenic in humans. These include a number of narcotic analgesics, chemotherapeutic drugs (antimetabolites, alkylating agents), anticonvulsants (trimethadione, valproic acid, fenithione, carbamazepine), androgens, warfarin, danazol, lithium, retinoids, thalidomide.

The safest drugs

(Larimore W.L., Petrie K.A., 2000)

It is very important that every pregnant woman remember that any drug during pregnancy can bring not only benefits, but also considerable harm, therefore, any self-administration during this period is not permissible, since their consequences are unpredictable and in many cases can cause irreparable harm to the developing fetus.

Early abortion pills

Medical abortion is one of the most gentle abortion options. It carries almost no risks for reproductive health, is highly effective and has a small list of side effects, but in any case, you need to resort to this method after a deliberate decision, because any termination of pregnancy is stressful for the body.

The procedure involves taking special pills to terminate pregnancy as early as 6 weeks. Abortion pills block the action of progesterone (a hormone responsible for the growth and development of the fetus) and cause uterine contractions to help the fetus out.

Today on the pharmaceutical market there are several preparations for abortion pills for short periods. Let's consider them in more detail.

Abortion pills (China)

The Chinese Pharmacological Corporation "Beijing Zizhu Pharmaceutical Co. Ltd." supplies the Russian market with drugs Mifepristone and Misoprostol, named after the name of the active substance. Do not be afraid of the inscription "China" on the packaging of tablets. These medicines are registered by the Ministry of Health of Russia and are used legally. Moreover, Chinese-made mifepristone complies with WHO requirements, has GMP and FDA certificates, and is used to terminate pregnancy in many countries of the world, and not only in the Russian Federation and China.

A woman takes one tablet of mifepristone 200 mg. The active substance is a steroid and blocks the hormone progesterone at the receptor level. Without the action of the hormone that supports pregnancy, the cervix softens, and part of the endometrium exfoliates. All this leads to the evacuation of the fetal egg.

1-3 days after taking mifepristone, the woman takes misoprostol. These tablets are responsible for the contractile activity of the uterus and the excretion of the fetus. Within a few days after the last pill, there may be cramping pains in the lower abdomen and bleeding comparable in volume to menstruation. Less common are general weakness, headaches, nausea and vomiting, and other side effects that can be found in the instructions for the drug.

Abortion using Russian drugs

Mifepristone is also produced in Russia. The drug is produced and taken in the same dosage of 200 mg, but in a higher dosage. It has the same effect - it does not allow progesterone to continue to support pregnancy, provokes contraction of the cervix and rejection of the mucosa with the fetus.

The second stage of abortion in pills is taking Topogin 1.5-2 days after Mifepristone. Topogin contains the active substance Misoprostol and is available in a dosage of 200 mcg. When a pregnancy is terminated, a woman is prescribed to take two tablets, which corresponds to a dosage of 400 mcg. This dose leads to contraction of the uterus and the withdrawal of the fetal egg from it.

For a few days after taking the first pill for medical abortion, a woman may experience vaginal bleeding, pain in the uterine area, as with menstruation. Weakness, nausea, vomiting, fever and other side effects are possible. The list of "side effects" of the Russian drug is similar to the Chinese one, but it is believed that the effectiveness of the Russian drug is higher and amounts to 98.8%. Also, an additional warranty card is given for Russian drugs - in case of complications (prolongation of pregnancy and the remains of the fetal egg), vacuum aspiration is free of charge, when taking Chinese-made drugs, this service is paid.

Abortion with French drugs

French drugs are also used in Russia for abortion. These tablets are registered in the Russian Federation, have certificates and other documents confirming the effectiveness and safety. On them, a pill abortion also takes place in two stages.

In the first stage of medical termination of pregnancy, the patient takes one tablet of Mifegin from the French pharmaceutical manufacturer MACORS Laboratoires. This tablet contains 200 mg of the active ingredient - mifepristone, which causes the same effect as that of Russian and Chinese counterparts. It blocks the effect of progesterone on a developing pregnancy, which leads to fetal death and rejection.

The second stage of the procedure is the intake of Topogin (French production by Delpharm Lille) at a dosage of 400 mcg. This drug helps to finally terminate the pregnancy - to ensure that the uterus contracts with sufficient force for the complete release of the fetal egg.

Some women have more confidence in European-made drugs and believe that they have fewer side effects. In the case of the French Mifegin, it has a “softer” effect on the body due to its micronized form and the effectiveness is no less than that of the Russian drug. These pills also cause menstrual-like discharge from the genital tract. Some time after taking the drugs may be accompanied by pain in the lower abdomen, headache, nausea and other adverse events. Also, a warranty card is given for French preparations - for the provision of an additional service - vacuum aspiration free of charge, in case of complications.

Where to buy abortion pills? These drugs can be used for abortion pills.

These drugs are not freely available in Russian pharmacies. Any pills bought on dubious resources or "from hand" can not only not lead to the desired result, but also provoke serious diseases of the reproductive system.

Original, effective and safe medicines are supplied only to medical institutions: private and public clinics with a valid license to provide obstetrics and gynecology services.

Abortion pills should only be taken under the supervision of a gynecologist. Usually, a complex procedure includes an ultrasound to determine the gestational age before and after taking the drugs. The first is carried out to control the duration of pregnancy and the place of attachment of the fetus, since pill abortion is not allowed for ectopic pregnancy and a period of more than 6 weeks. A control ultrasound on the 10-14th day after taking the drug with the active substance mifepristone is mandatory.

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