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At home pap smear


At Home High-Risk HPV Test - Completely Private

We accept HSA/FSA payments.

This test screens for 14 high-risk HPV genotypes

Your test results will tell you whether or not you test positive for high-risk genotypes of HPV. In the event that your test results are abnormal, you’ll have the opportunity to connect with our independent physician network at no additional cost to discuss your particular case.

HPV Screen

HPV has low-risk and high-risk genotypes. Low-risk genotypes are associated with papillomas (warts) and high risk genotypes are associated with an increased risk of developing cervical cancer. This test screens for 14 high-risk HPV strains (or genotypes)—16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68—and, if positive, will confirm if your infection is caused by HPV 16 or HPV 18/45.

HPV 16

HPV 16 is the most common high-risk genotype and can increase your risk of cervical cancer. Approximately 70% of all cervical cancer cases worldwide are caused by HPV 16 and 18 combined.

HPV 18/45

HPV 18 is a very common high-risk genotype and can increase your risk of cervical cancer. Although HPV 45 is less common, it’s still associated with 4% of cervical cancers and is typically tested with HPV 18.

Everything you need to understand your results

  • Pre-paid shipping both ways
  • All materials for sample collection and shipping back to the lab
  • Detailed directions and an instructional video to guide you
  • Help along the way from our customer care team
  • Digital and printable results

It’s recommended that you take this test if you’re a woman over 30 years old and want to understand your potential risk for cervical cancer. Frequency of testing can depend on your medical history (such as abnormal Pap results or cervical cancer in the past) but generally speaking, HPV testing is typically performed every 5 years. If you are unsure when testing may be right for you, we encourage you to follow up with your healthcare provider.

According to the CDC, 14 million people are newly infected with HPV each year, and nearly 12,000 women will be diagnosed with cervical cancer. HPV can clear on its own, which is why testing is not recommended for women under the age of 21. The time it takes for an HPV infection to develop into cervical cancer is about 15-20 years for women with normal immune systems, and the risk of developing cervical cancer under the age of 21 is rare. However, women over the age of 30 with a high-risk HPV infection are at an increased risk of developing cervical cancer.

Learn more: How to test for HPV

HPV testing for women: why it’s important

In the United States, cervical cancer screening is known to reduce the cervical cancer rate among women. In fact, cervical cancer cases have been declining since 1975 due to the Pap test, and screening with HPV high-risk tests (like the HPV DNA test or HPV mRNA test) further supported this downward trend when it became a recommended screening option by public health organizations in 2003. The Pap test and screening tests for high-risk, genital HPV strains offer a chance to catch cervical cancer early and seek treatment.

A Pap test and an HPV test for women can both check for genital HPV strains that can cause cervical cancer. During a Pap test, also known as a Pap smear, cervical cells are collected and examined with a microscope for signs of HPV (such as the presence of abnormal cervical cells). HPV tests for women, on the other hand, detect HPV DNA (the genetic material of the virus) in a vaginal sample. Both kinds of tests are often, but not always, done at the same time during routine cervical cancer screenings.

The American Cancer Society (ACS) and the American College of Obstetrics and Gynecology (ACOG) recommend that all women, even those who have had the HPV vaccine, following these screening guidelines:

  • Women ages 21–29 should be screened every three years with a Pap test
  • Women ages 30–65 should be screened every five years with a Pap test plus an HPV test

High-risk HPV genotypes can increase a woman's risk of forming precancerous lesions, which may progress to cervical and other types of genital cancers - like vulvar or anal - if the body is unable to clear the infection on its own. Low-risk HPV genotypes are not correlated with a risk of cervical cancer but are known to cause genital warts. If you suspect you have genital warts, please see your healthcare provider for treatment.

Although this HPV test does not diagnose cervical cancer, it tests to see if you’ve been infected with high-risk genotypes of HPV which can give a more complete picture of your cervical cancer risk. This will help you and your doctor make important decisions about additional testing and future prevention.

This HPV test for females will, with greater than 99% accuracy, tell you if you are infected with a high-risk type of HPV (for 14 different genotypes) and whether or not that infection is due to HPV 16 or HPV 18/45.

In the event that your HPV test result is abnormal, an associate from our physician network will contact you directly to discuss your particular case, as well as provide information about next steps.

However, we always recommend sharing the results with your healthcare provider who may perform additional testing. Additional testing may include a Pap smear if your HPV test result showed abnormal cells.

There are more than 100 different types of human papillomavirus (HPV). HPV types, or genotypes, are grouped into two categories: low-risk and high-risk. Low-risk HPV genotypes can cause genital warts, but are not known to cause cancer. A persistent high-risk HPV infection, on the other hand, can lead to cervical cancer-or cancer of the vagina, vulva, or anus.

A Pap smear is not the same as an HPV test, although both are used as cervical cancer screening methods.

  • Pap smear — In a pap smear, a sample of cells is taken from your cervix (a cervical specimen) and prepared for microscopic observation. A cytologist (an expert who specializes in microscopic examination of cells) then looks at the smear for abnormal cells that can indicate an HPV infection.
  • HPV test — In an HPV test, a vaginal swab can be used instead of cervical cells. The vaginal swab is checked for HPV's genetic material using DNA or mRNA testing technology. Because the vaginal swab can be collected at home, the HPV test is a convenient screening method.
  • Can you test for HPV from home? The answer is, “yes”: you can take an HPV test at home with our at-home collection kit. Just order an Everlywell HPV Test to get an easy-to-use, at-home collection kit that includes everything you need for collecting a vaginal swab and sending it to a lab for HPV testing.
  • Clinics in your community, your local Planned Parenthood, and your doctor/OB-GYN may all offer Pap smear tests.

The clinical validation that was performed by the CLIA-certified and CAP-accredited laboratory who will be processing your sample included a correlation study between the standard of care (cervical swab used for Pap tests) and the at-home collection device (vaginal swab used for HPV testing). These were both run on the same HPV assay and results showed 100% agreement between the different collection methods (n=40). This included positive and negative high-risk HPV screens, as well as confirmations for HPV 16 or HPV 18/45. In other words, the study showed that a vaginal swab for detection of HPV is just as effective as a cervical swab used for Pap smears.

While this test cannot provide a complete picture of your cervical cancer risk, it allows you to screen for HPV in the comfort of your own home so that you and your doctor can make immediate decisions about your health if results are positive. This screening test does not diagnose cervical cancer. Women should have routine cervical cancer screenings and gynecological exams to look for signs of precancerous changes of the cervix and genital skin that could lead to cancer if not treated.

There are more than 100 strains of HPV, and not all forms of HPV can be harmful. It’s not uncommon for an HPV infection to clear on its own without medical treatment, but we always recommend sharing the results with your doctor who can discuss next steps.

HPV is very common, and anyone who has ever had genital contact with another person (even with protection) can be HPV-positive. Both men and women can get HPV and can pass it to partners without knowing; however, the U.S Food and Drug Administration (FDA) has not approved a test for HPV in men.

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Exploring the Promise of At-Home Cervical Cancer Screening

Scientific breakthroughs in cancer screening have saved countless lives over the past several decades. But sometimes the biggest barrier to effective cancer screening isn’t science — it’s what people have to do to get screened.

Take cervical cancer screening. Nearly all cervical cancers can be prevented by identifying and removing precancers caused by certain high-risk strains of the human papillomavirus, or HPV. But despite how successful screening has been at reducing deaths from cervical cancer — leading to more than 50% fewer cases in the last 40 years — screening rates are declining across the United States. One in 4 women don’t receive regular screenings, and half of all diagnosed cervical cancers occur in women who are not screened.

When asked why they miss cervical cancer screenings, many people say they find them uncomfortable, embarrassing, and difficult to schedule. They also cite barriers such as lack of time and transportation to get to screening appointments.

Could we save more lives by offering an easier screening option? Researchers at Kaiser Permanente and other institutions are on a journey to find out. And what we’re learning could change the landscape of cervical cancer screening for patients everywhere.

What if cervical cancer screening could happen at home?

Most people have heard about at-home test kits for colorectal cancer screening. Research at Kaiser Permanente has shown that mailing these kits is an effective way to boost colorectal cancer screening rates. With that as a model, Kaiser Permanente conducted a study including 16,590 women age 30 to 65 to explore whether at-home testing for HPV could be an effective way to increase screening for cervical cancer, as well.

The home kits include everything a patient needs to collect a sample swab of vaginal cells to be tested for the HPV strains mostly likely to cause cervical cancer. Because of Kaiser Permanente’s integrated model, we were able to do our research alongside our normal care delivery. The patients returned their samples directly to our lab, and received results and follow-up care just like patients who had been screened in one of our clinics. Our research showed that samples collected at home detect HPV just as well as samples collected by a clinician.

Next, we examined the response rate when we mailed HPV testing kits to a sample of women who were overdue for cervical cancer screening. We found that mailing HPV kits increased screening by more than 50% compared to standard care. A follow-up survey showed that the women who returned the kits had very positive feelings about the experience.

Among the women who did not return the kit, the most common reasons were feeling unsure about how to use it correctly and not understanding why screening was necessary. This showed us that future outreach efforts should do a better job of explaining how the home HPV test kit works and what the results mean, in addition to explaining why getting screened is still important for people who have received their HPV vaccination, are monogamous, or are no longer sexually active.

We are working on addressing these barriers in an ongoing follow-up trial of 33,000 women. The study explores different outreach approaches based on participants’ prior screening behavior. It also tests different educational strategies to evaluate whether the information we provide can motivate individuals to get screened.

What’s next?

Although home HPV testing is used in several other countries, the kits have not yet been approved by the U.S. Food and Drug Administration for cervical cancer screening. Research like ours is providing important data that can help pave the way for their approval in the United States.

Making at-home HPV testing kits widely available, while still in the future, could give women a choice they’ve never had before. For some, that choice could save their lives. But it’s a choice that needs to come with the right amount of information at the right time.

Learn more about cancer care at Kaiser Permanente.

How to do a covid test at home: types of tests

Many people want to know if they are currently infected or have already been ill and have managed to develop antibodies due to the immune response. There has been a lot of confusion about coronavirus tests, and the FDA has said that some test developers have falsely claimed that their tests are FDA-approved or authorized, and that many commercial tests perform poorly, so getting the facts straight is important.

Coronavirus symptoms: how it all starts

The peculiarity of coronavirus infection is that at the very beginning it can be easily confused with a common acute respiratory viral infection caused, for example, by rhinovirus, since the new virus does not manifest itself immediately.

The first characteristic signs of COVID-19, which can be relied upon for comparison:

  • headache;
  • fever rises and feeling of tiredness increases;
  • muscles ache and body aches;
  • have cough;
  • breathing becomes difficult with time;
  • A characteristic feature of covid infection is that a person can stop smelling, they are either distorted, or the sense of smell disappears altogether. The taste is changing. But this does not happen to everyone;
  • manifestation of respiratory failure (appears about a week after the first symptoms during the transition of the disease from mild to moderate stage).

Therefore, as soon as you feel unwell, it is important to check yourself for infection as soon as possible. It’s convenient that you can do this at home on your own, because tests for covid have now become common and help in diagnosing for self-control.

But before we get into the details, let's start with a brief overview of the types of coronavirus tests.

What are the tests for coronavirus: two types

There are two types of rapid tests for coronavirus. The first determine the presence of an infection at the moment - they tell you that you are sick now or are currently a carrier. The second type determines specific antibodies to SARS-CoV-2 and reports that you have previously had a coronavirus infection and at the moment you have immunity to covid.

#1 Current Virus Test: PCR and Antigen

This test detects the SARS-CoV-2 virus to determine if you have an active infection and are contagious, that is, if you are spreading the infection to this moment. Although you can be contagious before any symptoms appear, this test detects the virus best about two weeks after infection or when symptoms first appear.

The coronavirus test is best done by taking a sample of mucus from a swab (usually from the nasopharynx or nostrils) or saliva.

There are two types of covid virus tests:

  • PCR;
  • antigen test .

Both tests must be analyzed in the laboratory or on a special portable fast machine.

PCR is done by amplifying the genetic material (RNA) of a virus. This may take from several minutes to several hours.

Another type of viral test is the antigen test. It identifies a protein that is specifically found in the virus. The advantages of the antigen test are that it can give results in as little as 15 minutes and can be produced at a lower cost, allowing it to be more widely used in screening (it is a rapid test). Also, only a nasal swab from the nostrils is needed, not a much deeper nasopharyngeal swab. The downside of antigen tests is that they are more likely to give a false negative result.

Only four laboratory antigen tests have been approved by the FDA so far:

  • Sofia 2 SARS Antigen FIA from Quidel Corporation,
  • BD Veritor System for Rapid Detection of SARS-CoV-2,
  • test LumiraDx SARS-CoV-2 Ag
  • Ag Card BinaxNOW COVID-19 from Abbott.

#2 Coronavirus Immunity Antibody Test

This test detects antibodies to the virus by drawing blood (drop or vial) to determine if you have been infected in the past and if you have developed a certain level of immunity. This test is best done in a lab, even with a test strip.

Because antibodies take time to develop, antibody tests are most accurate if taken at least 20 days after symptoms first appear. This was shown in a study of 486 patients with COVID-19, in whom the likelihood of a positive antibody (IgG) test result increased over time after testing positive for the virus.

Another way our body fights the virus is with T cells. Preliminary research shows that even if antibody levels are too low to be detected, people previously infected with the virus can produce a sufficient T-cell response to confer immunity. However, currently approved tests do not measure this type of immunity, and social distancing and health precautions should still be applied regardless of test results.

Home Rapid Tests for Coronavirus: Advantages and Disadvantages

The FDA has approved several virus tests for self-administration at home. There are two types: the antigen test and the PCR test, each with its pros and cons.

Home antigen tests provide results within 15 minutes. They can be used for people with symptoms or for observation - in the second case, you need to take the test twice within three days at least 36 hours apart.

Benefits of : Available without a prescription. Relatively inexpensive. Very fast.

Disadvantage of : Not as sensitive as PCR tests, so it is possible to miss the early and later phases of infection.

Total : If this test is positive, you may be highly contagious and will need to self-isolate and contact your healthcare provider.

False negative results can be obtained if the test is performed incorrectly. If the result is negative, you may still be contagious.

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What are the home tests for COVID-19 in Ukraine?

In our country, home rapid tests for coronavirus are represented by several positions. Below we will look at what their feature is and which one is better to choose.

Coronavirus antigen tests (for active infection):

  • CITO TEST COVID-19 Ag antigen test for coronavirus infection - detects coronavirus antigens by taking a nasopharyngeal swab. This is a high-quality and fast analysis with a visual account of the test results. If positive, if the sample contains SARS-CoV-2 antigens, a colored test line will form.
  • Testsealabs rapid test - determines the antigen of the COVID-19 virusand suitable for self-control. By taking a smear from the nasopharynx. Suitable for early diagnosis. The test has high sensitivity (92.1%) and specificity (98.1%), and you can see the result in 15 minutes.
  • NowCheck COVID-19 Ag Test rapid test - for rapid detection of antigens. It involves taking a smear from the nasopharynx. At the same time, its sensitivity is 90.4% and specificity is 99.5%.

Coronavirus antibody tests (to detect acquired immunity):

  • Cito Test COVID-19 neutralizing antibodies test - to detect immunity to coronavirus (post-infection and post-vaccination). Also suitable for self-monitoring and detects neutralizing antibodies to SARS-CoV-2 in human capillary blood. This type of test allows you to assess the level of immunity after an illness, evaluate the effectiveness of vaccination, and will also be useful for monitoring the dynamics of tension and the duration of immunity to COVID-19.
  • The CITO TEST COVID-19 Coronavirus Antibody Test is a rapid test for diagnosing pre-existing antibodies and immune response to coronavirus infection by drawing blood from a finger. It detects the presence of IgM and IgG to the coronavirus. So, usually IgM can be detected from the 7th day after the onset of the first symptoms.

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How to test yourself for coronavirus at home

Please read the safety precautions before proceeding with the swab collection procedure. These include the following steps:

  1. The test cannot be used if the expiration date has passed.
  2. Do not eat, drink or smoke at the test site. The room must be clean.
  3. If the package is damaged, it is better to replace the test with a new one - whole.
  4. Use only what is included in the test kit.
  5. Follow the procedure consistently and clearly. It is important to carry out sampling correctly, as indicated in the instructions.
  6. Failure to follow the procedure may result in inaccurate results.
  7. Specimens should be handled as potentially infectious material. Observe sterility, wash your hands before and after the procedure.
  8. If another person is sampling, he/she should wear disposable gloves and a face shield.
  9. When completed, place the test and used accessories in a plastic bag and discard in a waste container.

How to test?

Before taking a covid test, you need to take a swab. To collect a sample from the nasopharynx, you need to:

  1. Tilt your head back 45-70°.
  2. Slowly, with a slight movement of the hand, insert the tip of a sterile swab into the nostril and move it along the outer wall of the nose parallel to the palate to a depth of about 5 cm. For children, a depth of 3 cm is enough. You should feel the resistance of contact at the back of the nasopharynx.
  3. When you feel that the material rests against the back wall of the nasopharynx, begin to gently rotate the swab inside for a few seconds - this is enough for the swab to become saturated with secretion.
  4. Slowly rotate the swab out of the nasal cavity.

Another important thing to know: testing should be performed as soon as possible after sampling . In the event that it is not possible to perform the procedure quickly, place the swab with the sample in a dry, sterile and tightly closed storage tube. The sample can then be stored for 8 hours at room temperature and 24 hours at 2-8°C.

To properly prepare and store the swab sample:

  1. unscrew the cap of the buffer tube;
  2. insert a sterile swab into the buffer tube;
  3. rotate the swab for about 10 seconds while pressing the swab against the inner wall of the tube;
  4. then remove the swab by squeezing it out. It is necessary to compress the walls of the test tube in order to get the maximum amount of liquid from the swab;
  5. Close the tube tightly with a cap.

And now let's move on to the actual testing!

The procedure for testing is as follows:

  1. To do this, prepare all the materials necessary for testing: watch, test cassette, sterile swab, tube with buffer and sample. The materials are strictly those that are included in the kit.
  2. Make sure they are at room temperature.
  3. Open sealed pouch, remove test cassette from package and use within one hour.
  4. The best result can be obtained if the test is carried out immediately after opening the package.
  5. Place the test cassette on a clean and level surface.
  6. Unscrew the top of the cap of the sample vial, invert it and dispense 3 drops of the resulting mixture into the window of the cassette marked with the letter (S).
  7. Record the time.
  8. Post results after 15 minutes.
  9. Disregard test results later than 20 minutes.

Explanation of the result

The fact that the test is positive will be indicated by the appearance of two colored lines. One colored line should appear in the control zone (C) and another one in the test zone (T). A positive result indicates the presence of antigens or antibodies in the sample.

Negative: one colored line appears in the control zone (C). There will be no line in the test zone.

Invalid: no control line appears at all. The reason for this result may be an insufficient amount of the test sample, non-compliance with the testing procedure, expiration dates and storage conditions for quick tests. In this case, a different test cassette should be used, making sure that all precautions and rules are followed.

More than 200 coronavirus vaccines are currently in development, and some of them are already being actively used in many countries. But which one is considered the best in terms of efficiency and safety? Find out which coronavirus vaccine is leading: here is a comparison of CoronaVac, Pfizer, Moderna and Johnson & Johnson.

The issue of vaccination in Ukraine is very acute. The population is trying to develop immunity through the most popular and top vaccines. But no tool can guarantee a 100% result. Read more about why a vaccine may not work at all.

Learn more about health at apteka24.ua.

This editorial has been checked for authenticity by the family doctor of the First Mobile Clinic of Ukraine "DobroDoc +" - Deriy Natalia Valentinovna .

Sources

Interpreting Diagnostic Tests for SARS-CoV-2 / JAMA

Age- and Sex-Associated Variations in the Sensitivity of Serological Tests Among Individuals Infected With SARS-CoV-2 / JAMA

Coronavirus (COVID-19) Update: FDA Authorizes Antigen Test as First Over-the-Counter Fully At-Home Diagnostic Test for COVID-19 / FDA

Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19 / Biorxiv

Disclaimer

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Instructions for self-swabbing for coronavirus (Covid-19, Covid-19)

02/07/2022

Article Covid-19

Self-swabbing is a simple and safe procedure that, when performed correctly according to the instructions, provides the same testing accuracy as with the participation of medical staff

PATIENT INSTRUCTIONS RULES FOR COLLECTING A PCR PCR TEST FOR COVID-19

SARS-CoV-2 (COVID-19) RNA, qualitative determination

Attention! One set is for one patient only. Read this manual carefully before handling.

Contents of the set:

  • 3 probes (identical) for taking biomaterial

  • spatula (in case of difficult access to the oropharynx)

  • eppendorf (test tube) with transport medium

  • small zip bag for eppendorf test tubes

  • thermal bag (for packing the collected biomaterial)

  • shipping packaging

  • instructions for the patient "Rules for self-sampling of biological material to perform a study to detect coronavirus RNA"

  • contract for the provision of paid services in 2 copies (a copy of the license to carry out medical activities)

  • procedure for obtaining medical services

  • informed consent to the processing of personal data

  • informed voluntary consent of the patient to medical interventions

  • information for patients Clinics LLC "Concilium"

  • patient questionnaire

Swab preparation:

  • Taking biomaterial should be carried out no earlier than 2 hours after eating, or in the morning on an empty stomach.

  • It is allowed to carry out the procedure after eating, provided that the mouth is thoroughly rinsed.

  • Before taking a smear, do not use oropharyngeal sprays, tablets, lozenges and nasal drops / sprays, do not smoke.

  • If the nasal cavity is filled with mucus, it is necessary to blow your nose before taking the biomaterial!

It is more convenient to carry out self-sampling of a smear in front of a mirror in good light.

Step-by-step instruction

STEP 1

Fill in the documents:

  • contract for the provision of paid services in 2 copies (a copy of the license to carry out medical activities and keep one copy of the contract for yourself)

  • procedure for obtaining medical services

  • informed consent to the processing of personal data

  • informed voluntary consent of the patient to medical interventions

  • information for patients Clinics LLC "Concilium"

  • patient questionnaire

Check the passport data in the documents with yours and put your signature in the fields specially designated for this.

STEP 2

Wash your hands thoroughly before the procedure!

STEP 3

Take the biomaterial from the nasopharynx, following the rules:

  1. Remove one probe from the package (the probes are the same). The probe is sterile, so do not place it on other surfaces or touch other objects with it. Hold the probe in the hand that is more convenient for you to take a smear.

  2. Slightly tilt your head, place a thin probe in the right or left nasal passage.

  3. Carefully insert the probe along the outer (lateral) wall of the nasal passage (and not the nasal septum!) by about 4 cm - the length of the narrow part of the probe. Twist.

  4. Remove the probe along the outer wall of the nose.

  5. Take the eppendorf with your free hand, open the lid with your thumb.

  6. Place the probe into the test tube with the transport solution, perform rolling movements for 15-20 seconds, stirring the solution, squeeze the probe against the inner wall of the test tube.

  7. Completely remove the probe from the tube.

  8. Close the eppendorf lid until it clicks, set it aside.

  9. Dispose of the probe.

  10. Take the second probe and repeat the same steps (points 1-9) for the second nasal passage using the same tube.

STEP 4

  1. Collect biomaterial from the oropharynx, following the rules:
  2. Remove the third probe from the package.
  3. Tilt your head back slightly, open your mouth wide, inhale deeply.
  4. While inhaling, pass the hairy part of the probe along the right tonsil, then along the palatine arches to the uvula, then along the left tonsil and back of the pharynx. Do not touch the root of the tongue and palatine uvula, so as not to provoke a gag reflex. Attention! Do not touch the tongue with the probe. If necessary, fix the tongue with a spatula.
  5. Take the eppendorf with your free hand, open the lid with your thumb.

    Learn more

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